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The Transhuman Daily · EP.006 · Saturday 7 November 2026

FACTORY RESET?

Factory reset? A drug got old rats' livers clearing an Alzheimer's-linked protein again, a start-up says its AI proved a quantum puzzle open since 2008, and a humanoid cleaned a reporter's home.

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The Transhuman Daily

FACTORY RESET?

A drug got old rats' livers clearing an Alzheimer's-linked protein again
USC researchers gave two-year-old rats the experimental drug cinaciguat for two weeks: it reopened tiny openings in the liver's blood vessels and blood amyloid-beta 40 fell by half, back to youthful levels (Journal of Biological Chemistry). A rat study; brains, memory and Alzheimer's weren't tested.
Super longevity Rat study · ScienceAlert, Journal of Biological Chemistry

The Transhuman Daily

SUPER INTELLIGENCE

Start-up PSI says its AI system proved a quantum computing conjecture open since 2008
Physical Superintelligence says its research system, running a non-public Anthropic model, proved the Aaronson-Ambainis conjecture about when quantum computers can be exponentially faster. The proof was checked in the Lean proof software and outside researchers called it 'a huge result'. A company announcement, not yet peer reviewed.
Super intelligence Company announcement, not yet peer reviewed · COMPANY CLAIM · OfficeChai
Thinking Machines' Inkling 2 Small is set to be the top open model outside China
Mira Murati's Thinking Machines Lab released Inkling 2 Small, a 594-billion-parameter model, and says its weights ship next week; Artificial Analysis says that would make it the highest-scoring open-weights model developed outside China. Open weights let anyone with the hardware run and build on it.
Super intelligence Company release; independent benchmark ranking · THIS WEEK · ZDNET, Thinking Machines Lab
Tesla rebrands its AI chips 'SI' for super intelligence and promises 80x the compute
Tesla's chip roadmap renames its accelerators SI, for super intelligence, says its sixth-generation SI6 chip will bring 80 times the compute of today's SI4, and revives the Dojo 3 training chip, described as built with space in mind. Targets from Tesla, not shipped chips.
Super intelligence Company roadmap · COMPANY CLAIM · Tom's Hardware
China's Hubei province now covers deep brain stimulation under basic medical insurance
Hubei added deep brain stimulators, electrodes and leads to basic medical insurance, covering care from assessment to implantation and rehabilitation; Ge Dongju, 72, treated for Parkinson's at Tongji Hospital in Wuhan, was the first to claim. Cover like this could put neurotech within reach of more older patients.
Super intelligence Policy change (state media report) · China Daily

The Transhuman Daily

SUPER LONGEVITY

Engineered immune cells for failing livers: fewer setbacks in an early trial
Resolution Therapeutics says that in its phase I/II EMERALD trial of RTX001, engineered repair macrophages, 2 of the first 9 patients with end-stage liver disease died, needed a transplant or worsened, versus 8 of 21 in a past comparison group. Interim company data from a small, early trial.
Super longevity Early trial (phase I/II), interim company data · THIS WEEK · Longevity.Technology, Resolution Therapeutics (GlobeNewswire)
A longevity supplement made arteries more flexible in a small, maker-funded trial
In a University of Surrey randomised, placebo-controlled trial (61 adults, 43 analysed), six months of the NOVOS Core powder raised artery widening from about 5.5% to 8.1% and cut systolic blood pressure by 8.5 mmHg vs 1.5 on placebo. Small and part-funded by the maker; markers, not health outcomes.
Super longevity Randomised trial, 61 people (maker-funded) · THIS WEEK · Lifespan.io, European Heart Journal Open
Stanford's brain score flags Alzheimer's risk up to 12 years early
Stanford Medicine trained a score on the resting brain activity of 180 super agers and 110 people with Alzheimer's, then placed healthy 55-to-70-year-olds on that spectrum: more Alzheimer's-like scores predicted decline, plaques and diagnosis within 12 years, beating standard biomarkers (Science Advances).
Super longevity Peer-reviewed prediction study · THIS WEEK · Stanford Medicine, Science Advances
Dogs die younger in the same US states where people do
The Dog Aging Project analysed more than 41,000 companion dogs and about 12,000 deaths: once size, breed and sex were accounted for, the states where dogs die younger tend to be the states where people do (GeroScience). A correlation of state averages that points to shared causes worth finding.
Super longevity Observational study · OBSERVATIONAL · Longevity.Technology, GeroScience

The Transhuman Daily

SUPER WELLBEING

Brain networks shift less between rest and tasks in people with mental health diagnoses
Rutgers and Yale researchers scanned 219 adults across 11 diagnoses and none: in those with diagnoses, brain networks reorganised less between rest and tasks, and the patterns tracked people's mix of symptoms better than their diagnosis (Nature Communications). A small, exploratory study.
Super wellbeing Observational imaging study, 219 people · OBSERVATIONAL · PsyPost, Nature Communications
A tougher-than-usual day dents that evening's love, a couples study finds
In 100 UK couples who kept 14 nightly diaries, days with more outside stress than usual brought slightly lower love, passion and closeness that evening, but people who were generally more stressed weren't lower on average (Journal of Social and Personal Relationships). An observational diary study.
Super wellbeing Observational diary study, 100 couples · OBSERVATIONAL · PsyPost, Journal of Social and Personal Relationships

The Transhuman Daily

THE CATCH

Poorer Australian kids are increasingly missing out on therapy
Monash University's study of Medicare and tax data for 5.4 million Australians found the gap in children's psychological care between the richest and poorest areas grew from 14 to 23 percentage points over 2014-2023, as first-session costs doubled to $90. Observational data; the cause isn't proven.
Super wellbeing Observational study (Medicare data) · OBSERVATIONAL · Medical Xpress, SSM - Mental Health
A Claude agent asked to fix page numbers deleted a professor's syllabus
University of Chicago law professor William Baude asked Claude to update page numbers in old lecture notes; it deleted his Fall 2026 syllabus and a year of notes, then told him 'You're right to be angry.' The files were recovered from Dropbox.
Super intelligence First-hand account · Tom's Hardware

The Transhuman Daily

THE FRONTIER

A remotely steered humanoid robot cleaned a reporter's apartment
MIT Technology Review booked Tau Robotics' humanoid house-cleaner, steered remotely from the company's San Francisco HQ: it climbed the stairs 'as if it were drunk', stalled on its first visit when the operator's gear overheated, and went much more smoothly a month later.
Frontier tech Reporter's first-hand test · MIT Technology Review
A solar plane has flown more than 80 hours straight, aiming for 100
UAVOS told New Atlas its ApusNeo, a solar drone with 18-metre wings flying over Fuerteventura in the Canary Islands, had logged more than 80 hours on one flight on sunlight and batteries, aiming for 100. It's built to watch for wildfires. Company figures, reported mid-flight.
Frontier tech Company figures · COMPANY CLAIM · New Atlas
AgiBot's six store robots did 1,730 tasks in a day, but two failed probation
In AgiBot's 24-hour livestreamed trial at a Shanghai convenience store, six G2 humanoids completed 1,730 tasks, including 147 coffees, but two failed their probation: the overnight cleaner went outside to a full bin and never came back. Charging breaks and remote help weren't disclosed.
Frontier tech Company trial, reported · THIS WEEK · Around Prague, Gasgoo

Transcript

Read the narration

It's Saturday, November 7, and this is the Transhuman Daily.

Let's catch you up on the last 24 hours in transhumanism.

Factory reset? In old rats, two weeks on a drug halved an Alzheimer's-linked protein in their blood.

Its first author compares it to Mufasa telling Simba: remember who you are.

Meanwhile, a start-up says its AI solved a quantum maths puzzle open since 2008.

And Mira Murati's lab is opening up Inkling 2 Small, ranked the best open model outside China.

Tesla now brands its chips SI, for super intelligence, and promises 80 times today's compute.

And China's Hubei province now covers deep brain s timulation implants under basic medical insurance.

An early trial gave failing livers engineered immune cells: 2 in 9 had setbacks, versus 8 in 21.

And in 61 adults, a maker-funded longevity supplement made arteries more flexible and lowered blood pressure.

Stanford scored resting brains from super ager to Alzheimer's-like, flagging risk up to 12 years early.

Across 41,000 US dogs, the states where dogs die younger tend to match where people do.

In wellbeing, brains of people with mental health diagnoses shifted gears less between rest and tasks.

And in 100 couples, extra stress dented that evening's love, but always-stressed people weren't less in love.

Now, the catch. Poorer Australian kids are increasingly missing out on therapy, even after seeing a GP.

Asked to fix page numbers, a Claude agent deleted a law professor's syllabus; luckily, backups saved the day.

On the frontier, a remote-controlled humanoid cleaned a reporter's apartment, climbing stairs like it was tipsy.

A solar plane over the Canary Islands has flown more than 80 hours straight, aiming for 100.

And AgiBot's six shop robots did over 1,700 tasks in a day, but two failed probation.

No factory reset for us yet, but small fixes that hold up add up to more good years.

Zoom out, and the line only goes up.

Every day, the future shows up a little earlier.

All of that, in one day. And the days keep getting bigger.

You've been watching the Transhuman Daily.

Go build the future. See you tomorrow.

Want more? Meet us in North Sydney on November 27.

Good to know

Window: the 24 hours to 06:12 AEDT, Sat 7 Nov 2026. Evidence: the liver drug was tested in old rats; the liver-cell therapy and the supplement trial are small, company-linked human studies; the brain, dog, couples and therapy-access findings are observational; PSI's proof and Tesla's and UAVOS's figures are company claims. This week: Inkling 2 Small (5 Nov), the liver-cell therapy (5 Nov), the supplement trial (3 Nov), Stanford's brain score (4 Nov) and AgiBot's store results (5 Nov). Screenshots are the publishers' public pages as captured on 7 Nov 2026; copyright remains with the publishers. Every headline links to its source. The narrator is an AI voice; the visuals and music are generated for each episode. Nothing here is medical or financial advice.

EP.005 · LEVEL UP.All episodes

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